Eagon Research Group - Publications

Publications
Undergraduate Co-Authors are Underlined

27. Troftgruben, Mark H. S.; Oldenburg, Isabella; Pama, Alyssa M.; Igawa, Bryce; Deguara, Salvatore; Shields, Maya; Viswanathan, Neil K.; Silverio, Joshua X.; Gleason, Cameron; Wang, Justin Shan-Ming; Ford, Jordan S.; Lazaro, Horacio; Eagon, Scott. Microwave Mediated Acylation of Alcohols, Phenols and Thiophenols in Neat Acetic Anhydride. J. Org. Chem., 2024, in press.

26. Viswanathan, Neil K.; Chirgwin, Michael E.; Gibbs, Julia; Kalaj, Brianna N.; Durham, Sierra; Tran, Jennifer; Gomez, Maximllian; Lazaro, Horacio, Ming, Chen; Mansfield, Christopher R.; Derbyshire, Emily R.; Eagon, Scott. Synthesis and Activity of β-Carboline Antimalarials Targeting the Plasmodium falciparum Heat Shock 90 Protein. Bioorg. Med. Chem. Lett., 2023, 92, 129410. (Link)

25. Wong, Chloe D.; Ganjooi, Kimiya; Verbarendse, Maetja; Travis, Jessica M.; Troftgruben, Mark H. S.; Mora, Hannah R.; Oldenburg, Isabella; Lammert, Robert Jr.; Lazaro, Horacio; Eagon, Scott. Synthesis of Benzoxazoles via a Silver Mediated Oxidation. Synth. Commun., 2023, 53, 32-39. (Link)

24. Johnson, Hunter; Gleason, Cameron; Klug, Trevan; Schmid, Connor; Schioldager, Ryan; DiBernardo, Celine; Eagon, Scott. Improved Synthesis of 5-Ethylsulfonyl-2-methoxyaniline. Org. Prep. Proced. Int., 2022, 54, 435-439. (Link)

23. Klug, Trevan; Cronin, Adam; O'Brien, Eli; Schioldager, Ryan; Johnson, Hunter; Gleason, Cameron; Schmid, Connor; Soderberg, Nathan; Manjunath, Aashrita; Liyanage, Duminda; Lazaro, Horacio, Kimball, Joshua J.; Eagon, Scott. Microwave Mediated Synthesis of 2-Aminooxazoles. Tetrahedron Lett., 2022, 88, 153555. (Link)

22. Eagon, Scott; Howland, McClane; Heying, Michael; Callant, Emma; Brar, Nimrat; Pompa, Emmett; Mallari, Jeremy P. Identification of Plasmodium falciparum Falcilysin Inhibitors by a Virtual Screen. Bioorg. Med. Chem. Lett., 2021, 52, 128394. (Link)

21. Eagon, Scott; Hammill, Jared T.; Fitzsimmons, Kasey; Sienko, Natalie; Nguyen, Brandon; Law, Jarvis; Manjunath, Aashrita; Wilkinson, Steven P.; Thompson, Kara; Glidden, Julia Elizabeth; Rice, Amy L.; Falade, Mofolusho O.; Kimball, Joshua J.; DiBernardo, Celine; Guy, R. Kiplin. Antimalarial Activity of 2,6-Dibenzylidenecyclohexanone Derivatives. Bioorg. Med. Chem. Lett., 2021, 47, 128216. (Link)

20. Zhang, Linlin; Howland, McClane; Hilgenfeld, Rolf; Anderson, Marc O.; Eagon, Scott. Identification of Non-Covalent SARS-CoV-2 Main Protease Inhibitors by a Virtual Screen of Commercially Available Drug-Like Compounds. Bioorg. Med. Chem. Lett., 2021, 41, 127990. (Link)

19. Everson, Nikalet; Bach, Jordan; Hammill, Jared T.; Falade, Mofolusho O.; Rice, Amy L.; Guy, R. Kiplin; Eagon, Scott. Identification of Plasmodium falciparum Heat Shock 90 Inhibitors via Molecular Docking. Bioorg. Med. Chem. Lett., 2021, 35, 127818. (Link)

18. Kahlon, Gulbag; Lira, Rogelio; Maslov, Nikolay; Pompa, Emma; Brar, Nimrat; Eagon, Scott; Anderson, Marc O.; Andaya, Armann; Chance, Jeff P.; Fejzic, Hannah; Keniston, Aaron; Huynh, Ngoc; Celis, Nohemi; Vidal, Brian; Trieu, Nicholas; Rodriguez, Paulina; Mallari, Jeremy P. Structure Guided Development of Potent Piperazine-Derived Hydroxamic Acid Inhibitors Targeting Falcilysin. Bioorg. Med. Chem. Lett., 2021, 32, 127683. (Link)

17. Eagon, Scott; Hammill, Jared T.; Sigal, Martina; Ahn, Kevin J.; Tryhorn, Julia E.; Koch, Grant; Belanger, Briana; Chaplan, Cory A.; Loop, Lauren; Kashtanova, Anna S.; Yniquez, Kenya; Lazaro, Horacio; Wilkinson, Steven P.; Rice, Amy L.; Falade, Mofolusho O.; Takahashi, Rei; Kim, Katie; Cheung, Ashley; DiBernardo, Celine; Kimball, Joshua J.; Winzeler, Elizabeth A.; Eribez, Korina; Mittal, Nimisha; Gamo, Francisco-Javier; Crespo, Benigno; Churchyard, Alisje; Garcia-Barbazan, Irene; Baum, Jake; Anderson, Marc O.; Laleu, Beniot; Guy, R. Kiplin. Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4-b]pyridines. J. Med. Chem. 2020, 63, 11902-11919. (Link)

16. Eagon, Scott; Hammill, Jared T.; Bach, Jordan; Everson, Nikalet; Sisley, Tyler A.; Walls, Michael J.; Durham, Sierra; Pillai, Dylan R.; Falade, Mofolusho O.; Rice, Amy L.; Kimball, Joshua J.; Lazaro, Horacio; DiBernardo, Celine; Guy, R. Kiplin. Antimalarial Activity of Tetrahydro-β-carbolines Targeting the ATP Binding Pocket of the Plasmodium falciparum Heat Shock 90 Protein. Bioorg. Med. Chem. Lett. 2020, 30, 127502. (Link)

15. Masters, Lily; Eagon, Scott; Heying, Michael. Evaluation of Consensus Scoring Methods for AutoDock Vina, Smina and iDock. J. Mol. Graph. Model. 2020, 96, 107532. (Link)

14. Law, Jarvis; Manjunath, Aashrita; Schioldager, Ryan; Eagon, Scott. Microwave-Assisted Preparation of 1-Aryl(1H)-pyrazole-5-amines. J. Vis. Exp., 2019, 148, e59896. (Link)

13. Bowen, Lucy R.; Li, Dennis J.; Nola, Derek T.; Anderson, Marc O.; Heying, Michael; Groves, Adam T.; Eagon, Scott. Identification of Potential Zika Virus NS2B-NS3 Protease Inhibitors via Docking, Molecular Dynamics and Consensus Scoring-Based Virtual Screening. J. Mol. Model., 2019, 25, 194. (Link)

12. Everson, Nikalet; Yniguez, Kenya; Loop, Lauren; Lazaro, Horacio; Belanger, Briana; Koch, Grant; Bach, Jordan; Manjunath, Aashrita; Schioldager, Ryan; Law, Jarvis; Grabenauer, Megan; Eagon, Scott. Microwave Synthesis of 1-Aryl-1H-pyrazole-5-amines. Tetrahedron Lett., 2019, 60, 72-74. (Link)

11. Durham, Sierra; Sierra, Brianna; Gomez, Maximillian; Tran, Jennifer; Anderson, Marc; Whittington-Davis, Nick; Eagon, Scott. Synthesis of β-Carbolines via a Silver-Mediated Oxidation of Tetrahydro-β-carbolines. Tetrahedron Lett., 2017, 58, 2747. (Link)

10. Bayih, Abebe; Folefoc, Asonga; Mohon, Abu; Eagon, Scott; Anderson, Marc; Pillai, Dylan. In Vitro and In Vivo Anti-Malarial Activity of Novel Harmine-Analog Heat Shock Protein 90 Inhibitors: A Possible Partner for Artemisinin. Malar. J. 2016, 15, 579. (Link)

9. Eagon, Scott; Anderson, Marc. Microwave-Assisted Synthesis of Tetrahydro-β-carbolines and β-Carbolines. Eur. J. Org. Chem. 2014, 8, 1653-1665. (Link)

8. Bailey, Christopher; Murphy, Chris; Clary, Jacob; Eagon, Scott; Gould, Naomi; Singaram, Bakthan. Reaction of Grignard Reagents with Diisopropylaminoborane. Synthesis of Alkyl, Aryl, Heteroaryl, and Allyl Boronic Acids from Organo(diisopropyl)aminoborane by a Simple Hydrolysis. Heterocycles 2012, 86, 331-342. (Link)

7. Saavedra, Jaime; Resendez, Angel; Rovira, Alexander; Eagon, Scott; Haddenham, Dustin; Singaram, Bakthan. Reaction of In₃Cl with Various Reducing Agents: In₃Cl-NaBH₄ Mediated Reduction of Aromatic and Aliphatic Nitriles to Primary Amines. J. Org. Chem. 2012, 77, 221-228. (Link)

6. Haddenham, Dustin; Baily, Christopher; Vu, Chau; Nepomuceno, Gabby; Eagon, Scott; Pasumansky, Lubov; Singaram, Bakthan. Lithium Aminoborohydrides 17. Palladium Catalyzed Borylation of Aryl Iodides, Bromides, and Triflates with Diisopropylaminoborane Prepared from Lithium Diisopropylaminoborohydride. Tetrahedron 2011, 67, 576-583. (Link)

5. Eagon, Scott; Ball-Jones, Nicholas; Haddenham, Dustin; Saavedra, Jaime; DeLieto, Cassandra; Buckman, Matthew; Singaram, Bakthan. Enantioselective reduction of α-Substituted Ketones Mediated by the Boronate Ester TarB-NO₂. Tetrahedron Lett. 2010, 51, 6418-6421. (Link)

4. Eagon, Scott; DeLieto, Cassandra; McDonald, William; Haddenham, Dustin; Saavedra, Jaime; Kim, Jinsoo; Singaram, Bakthan. Mild and Expedient Asymmetric Reductions of α,β-Unsaturated Alkenyl and Alkynyl Ketones by TarB-NO2 and Mechanistic Investigations of Ketone Reduction. J. Org. Chem. 2010, 75, 7717-7725. (Link)

3. Haddenham, Dustin; Pasumansky, Lubov; DeSoto, Jamie; Eagon, Scott; Singaram, Bakthan. Reductions of Aliphatic and Aromatic Nitriles to Primary Amines with Diisopropylaminoborane. J. Org. Chem. 2009, 74, 1964-1970. (Link)

2. Eagon, Scott; Kim, Jinsoo; Singaram, Bakthan. Mild and Practical Reductions of Prochiral Ketones to Alcohols Using the Chiral Boronic Ester TarB-H. Synthesis 2008, 23, 3874-3876. (Link)

1. Eagon, Scott; Kim, Jinsoo; Yan, Katie; Haddenham, Dustin; Singaram, Bakthan. Asymmetric Reductions Using the Chiral Boronic Ester TarB-H: a Practical and Inexpensive Procedure for Synthesizing Chiral Alcohols. Tetrahedron Lett. 2007, 48, 9025-9029. (Link)